The connective tissue in the body, which holds all of the body’s cells, organs, and tissue together and is crucial for proper growth and development, is impacted by Marfan syndrome, a genetic disorder.
Fibrillin-1, a protein involved in Marfan syndrome, is a component of connective tissue and is produced by the body when there is a defect (or mutation) in the gene that directs the production of this protein.
About 1 in 5,000 people have Marfan syndrome,
men and women of all races and ethnic groups.
About 3 out of 4 people with Marfan syndrome inherit itThere is a 50% chance that a person with Marfan syndrome will pass along the genetic mutation each time they have a child, meaning that some people with Marfan syndrome are the first in their family to have it; when this occurs, it is known as a spontaneous mutation.
Symptoms of Marfan Syndrome
Marfan syndrome is a condition that has a wide range of signs and symptoms, even among members of the same family. In most cases, the condition tends to get worse with age, with some people experiencing only mild symptoms while others experience life-threatening complications.
Features of the Marfan syndrome could be:
- Tall and slender build
- long fingers, legs, and arms in relation to body size
- An outwardly or inwardly dipping breastbone
- a high palate with an arch and crowded teeth
- Heart murmurs
- Extreme nearsightedness
- An abnormally curved spine
- Flat feet
Causes of Marfan Syndrome
The gene that allows the body to produce a protein that contributes to the elasticity and strength of connective tissue has a defect in Marfan syndrome, which leads to the condition.
Each child of a parent with Marfan syndrome has a 50/50 chance of inheriting the defective gene; however, in about 25% of those with Marfan syndrome, the abnormal gene does not come from either parent; instead, a new mutation arises spontaneously.
Complications
Cardiovascular complications
The largest artery that emerges from the heart and supplies blood to the body, the aorta, can become weak due to faulty connective tissue, making it one of the most dangerous complications of Marfan syndrome.
- Aortic aneurysm –In people with Marfan syndrome, this is most likely to occur at the aortic root — where the artery leaves your heart. The pressure of blood leaving your heart can cause the wall of your aorta to bulge out, similar to a weak spot in a tire.
- Aortic dissection –Aortic dissection weakens the structure of the vessel and can lead to a rupture, which may be fatal. It happens when a small tear in the innermost layer of the aorta’s wall allows blood to squeeze in between the inner and outer layers of the wall.
- Valve malformations –When heart valves don’t function properly, your heart has to work harder to make up for it, which can eventually result in heart failure. People with Marfan syndrome may have heart valves that have weaker tissue than normal, which can cause stretching of the valve tissue and abnormal valve function.
Eye complications
Eye complications may include:
- Lens dislocation.The medical term for this issue is ectopia lentis, and it occurs in more than half of those with Marfan syndrome. Ectopia lentis is a problem where the focusing lens within your eye can move out of place if its supporting structures weaken.
- Retinal problems.The retina, the light-sensitive tissue that lines the back wall of your eye, is also more prone to detachment or tear in people with Marfan syndrome.
- Early-onset glaucoma or cataracts.Glaucoma increases intraocular pressure, which can harm the optic nerve; cataracts are cloudy areas in the normally clear lens of the eye; and Marfan syndrome patients are more likely to experience these eye conditions at a younger age.
Skeletal complications
Marfan syndrome can interfere with the normal growth of the ribs, causing the breastbone to either protrude or appear sunken into the chest, and it can increase the risk of abnormal curves in the spine, such as scoliosis. It is also common for Marfan syndrome to cause foot pain and low back pain.
Complications of pregnancy
Because a woman’s heart is pumping more blood than usual while she is pregnant, her aorta may be under additional stress, which raises the risk of a fatal dissection or rupture. Marfan syndrome can weaken the walls of the aorta, the main artery that leaves the heart.
Homeopathic Treatment of Marfan Syndrome
The following are some examples of homeopathic medicines that can be used to treat Marfan Syndrome:
- Phosphorus
- Calc phos
- Mag phos
- Plumbum
- Zincum,e.t..c
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